Dr. Andrew P. Feinberg, MD, MPH. Director of the Center for Epigenetics and King Fahd Professor of Medicine, Oncology, and Molecular Biology & Genetics, Johns Hopkins University School of Medicine
Dr. Feinberg will address important developments in epigenetics, a branch of science that studies the biochemical modifications of the genome. His early work included the discoveries of altered DNA methylation in human cancer, human imprinted genes and loss of imprinting (LOI) in cancer, and the molecular basis of Beckwith-Wiedemann syndrome and epigenetic risk of cancer. Most recently, he pioneered genome-scale epigenetics (epigenomics), with the first whole genome bisulfite sequencing analysis of human cancer, and the discovery of large hypomethylated blocks that correspond to nuclear lamina-associated heterochromatin, as well as a mechanism for disruption of these blocks in epithelial-mesenchymal transition. He has shown the close relationship between epigenomics changes in normal development, cancer, and stem cell reprogramming. These developments have exciting implications to molecular diagnostics and novel forms of therapy.
The Epigenetic Basis of Common Human Disease will take you on a journey into the biochemical modifications of the genome. Dr. Andrew Feinberg has made fundamental discoveries in the field, impacting diverse fields ranging from cancer, stem cells, molecular diagnostics, and novel therapeutics.
Read the CLN Daily article: More than DNA Sequence: Epigenetics in Human Disease
Source: AACC
